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Article

Biology of high single doses of IORT: RBE, 5 R’s, and other biological aspects

19 Jan 2017

Abstract excerpt

Intraoperative radiotherapy differs from conventional, fractionated radiotherapy in several aspects that may influence its biological effect. The radiation quality influences the relative biologic effectiveness (RBE), and the role of the five R's of radiotherapy (reassortment, repair, reoxygenation, repopulation, radiosensitivity) is different. Furthermore, putative special biological effects and the small volume...

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PMID: 28107823
DOI: 10.1186/s13014-016-0750-3

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