Article
The dynamics of the pulmonary microbiome during mechanical ventilation in the intensive care unit and the association with occurrence of pneumonia.
Thorax - 1 Sept 2017
Zakharkina Tetyana, Martin-Loeches Ignacio, Matamoros Sébastien, Povoa Pedro, Torres Antoni, Kastelijn Janine B, Hofstra Jorrit J, de Wever B, de Jong Menno, Schultz Marcus J, Sterk Peter J, Artigas Antonio, Bos Lieuwe D J
Abstract excerpt
RATIONALE: Ventilator-associated pneumonia (VAP) is the most common nosocomial infections in patients admitted to the ICU. The adapted island model predicts several changes in the respiratory microbiome during intubation and mechanical ventilation. OBJECTIVES: We hypothesised that mechanical ventilation and antibiotic administration decrease the diversity of the respiratory microbiome and that these changes are...
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