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Article

Transdifferentiation of Human Dermal Fibroblasts to Smooth Muscle-Like Cells to Study the Effect of MYH11 and ACTA2 Mutations in Aortic Aneurysms.

Human mutation - 1 Apr 2017

Yeung Kak K, Bogunovic Natalija, Keekstra Niels, Beunders Adriaan A M, Pals Jorrit, van der Kuij Kim, Overwater Eline, Wisselink Willem, Blankensteijn Jan D, van Hinsbergh Victor W M, Musters Rene J P, Pals Gerard, Micha Dimitra, Zandieh-Doulabi Behrouz

Abstract excerpt

Mutations in genes encoding proteins of the smooth muscle cell (SMC) contractile apparatus contribute to familial aortic aneurysms. To investigate the pathogenicity of these mutations, SMC are required. We demonstrate a novel method to generate SMC-like cells from human dermal fibroblasts by transdifferentiation to study the effect of variants in genes encoding proteins of the SMC contractile apparatus (ACTA2 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28074631
DOI: 10.1002/humu.23174

Genes

ACTA2
MYH11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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