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Article

A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers.

Science translational medicine - 4 Jan 2017

Stone Rivka C, Stojadinovic Olivera, Rosa Ashley M, Ramirez Horacio A, Badiavas Evangelos, Blumenberg Miroslav, Tomic-Canic Marjana

Abstract excerpt

Chronic nonhealing venous leg ulcers (VLUs) are widespread and debilitating, with high morbidity and associated costs; about $15 billion is spent annually on the care of VLUs in the United States. Despite this, there is a paucity of treatments for VLUs because of the lack of pathophysiologic insight into ulcer development as well as the lack of knowledge regarding biologic actions of existing VLU-targeted...

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Identifiers

PMID: 28053158
DOI: 10.1126/scitranslmed.aaf8611
PMCID: PMC5472448

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