Article
BRCA1-IRIS overexpression promotes and maintains the tumor initiating phenotype: implications for triple negative breast cancer early lesions.
Oncotarget - 7 Feb 2017
Sinha Abhilasha, Paul Bibbin T, Sullivan Lisa M, Sims Hillary, El Bastawisy Ahmed, Yousef Hend F, Zekri Abdel-Rahman N, Bahnassy Abeer A, ElShamy Wael M
Abstract excerpt
Tumor-initiating cells (TICs) are cancer cells endowed with self-renewal, multi-lineage differentiation, increased chemo-resistance, and in breast cancers the CD44+/CD24-/ALDH1+ phenotype. Triple negative breast cancers show lack of BRCA1 expression in addition to enhanced basal, epithelial-to-mesenchymal transition (EMT), and TIC phenotypes. BRCA1-IRIS (hereafter IRIS) is an oncogene produced by the alternative...
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