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Article

Base-Position Error Rate Analysis of Next-Generation Sequencing Applied to Circulating Tumor DNA in Non-Small Cell Lung Cancer: A Prospective Study.

PLoS medicine - 1 Dec 2016

Pécuchet Nicolas, Zonta Eleonora, Didelot Audrey, Combe Pierre, Thibault Constance, Gibault Laure, Lours Camille, Rozenholc Yves, Taly Valérie, Laurent-Puig Pierre, Blons Hélène, Fabre Elizabeth

Abstract excerpt

BACKGROUND: Circulating tumor DNA (ctDNA) is an approved noninvasive biomarker to test for the presence of EGFR mutations at diagnosis or recurrence of lung cancer. However, studies evaluating ctDNA as a noninvasive "real-time" biomarker to provide prognostic and predictive information in treatment monitoring have given inconsistent results, mainly due to methodological differences. We have recently validated a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28027313
DOI: 10.1371/journal.pmed.1002199
PMCID: PMC5189949

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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