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Article

Tract-specific atrophy in focal epilepsy: Disease, genetics, or seizures?

Annals of neurology - 1 Feb 2017

Vaughan David N, Raffelt David, Curwood Evan, Tsai Meng-Han, Tournier Jacques-Donald, Connelly Alan, Jackson Graeme D

Abstract excerpt

OBJECTIVE: To investigate whether genetics, underlying pathology, or repeated seizures contribute to atrophy in specific white matter tracts. METHODS: Medically refractory unilateral temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS-TLE, n = 26) was studied as an archetype of focal epilepsy, using fixel-based analysis of diffusion-weighted imaging. A genetic effect was assessed in first-degree relatives...

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PMID: 28009132
DOI: 10.1002/ana.24848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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