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Article

An increased duplication of ZRS region that caused more than one supernumerary digits preaxial polydactyly in a large Chinese family.

Scientific reports - 6 Dec 2016

Wang Bin, Diao Yutao, Liu Qiji, An Hongqiang, Ma Ruiping, Jiang Guosheng, Lai Nannan, Li Ziwei, Zhu Xiaoxiao, Zhao Lin, Guo Qiang, Zhang Zhen, Sun Rong, Li Xia

Abstract excerpt

Preaxial polydactyly (PPD) is inherited in an autosomal dominant fashion and characterized by the presence of one or more supernumerary digits on the thumb side. It had been identified that point mutation or genomic duplications of the long-range limb-specific cis-regulator - zone of polarizing activity regulatory sequence (ZRS) cause PPD or other limb deformities such as syndactyly type IV (SD4) and...

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PMID: 27922091
DOI: 10.1038/srep38500
PMCID: PMC5138840

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