Article
Quantitative assessment of polymorphisms in H19 lncRNA and cancer risk: a meta-analysis of 13,392 cases and 18,893 controls.
Oncotarget - 29 Nov 2016
Chu Minjie, Yuan Weiyan, Wu Shuangshuang, Wang Zhiquan, Mao Liping, Tian Tian, Lu Yihua, Zhu Bowen, Yang Yue, Wang Bin, Gao Haiquan, Jiang Liying, Zhuang Xun
Abstract excerpt
H19 refers to a long non-coding RNA (lncRNA) that functions as an oncogenic molecule in different cancer cells. Genetic variants of H19 may affect the activity of certain regulatory factors, which subsequently regulate the aberrant expression of H19. This feedback loop might be one of the underlying mechanisms influencing tumour susceptibility and prognosis. Although there have been several recent studies that...
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