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Massively parallel sequencing of 68 insertion/deletion markers identifies novel microhaplotypes for utility in human identity testing.

Forensic science international. Genetics - 1 Nov 2016

Wendt Frank R, Warshauer David H, Zeng Xiangpei, Churchill Jennifer D, Novroski Nicole M M, Song Bing, King Jonathan L, LaRue Bobby L, Budowle Bruce

Abstract excerpt

Short tandem repeat (STR) loci are the traditional markers used for kinship, missing persons, and direct comparison human identity testing. These markers hold considerable value due to their highly polymorphic nature, amplicon size, and ability to be multiplexed. However, many STRs are still too large for use in analysis of highly degraded DNA. Small bi-allelic polymorphisms, such as insertions/deletions...

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PMID: 27685342
DOI: 10.1016/j.fsigen.2016.09.005

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