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Uterosome-like vesicles prompt human sperm fertilizing capability

27 Sept 2016

Abstract excerpt

STUDY QUESTION: Does the rapid transit through the uterine environment modulate the sperm physiological state? SUMMARY ANSWER: The uterosome-like vesicles (ULVs) secreted by endometrial epithelial cells (EECs) in vitro are able to fuse with human spermatozoa, prompting their fertilizing capacity. WHAT IS KNOWN ALREADY: Early studies suggest that sperm capacitation begins in the uterus and ends in the oviduct, and...

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PMID: 27678485
DOI: 10.1093/molehr/gaw066

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