Article
Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei.
PLoS neglected tropical diseases - 1 Aug 2016
Woo Patrick C Y, Lau Susanna K P, Lau Candy C Y, Tung Edward T K, Chong Ken T K, Yang Fengjuan, Zhang Hongmin, Lo Raymond K C, Cai Jian-Pao, Au-Yeung Rex K H, Ng Wing-Fung, Tse Herman, Wong Samson S Y, Xu Simin, Lam Wai Hei, Tse Man-Kit, Sze Kong Hung, Kao Richard Y, Reiner Neil E, Hao Quan, Yuen Kwok-Yung
Abstract excerpt
BACKGROUND: Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate protective immunity, we hypothesized that Mp1p and/or its homologs are virulence factors. METHODOLOGY/PRINCIPAL FINDINGS: We examined the pathogenic roles of...
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