Article
Variable Cell Growth Yields Reproducible OrganDevelopment through Spatiotemporal Averaging.
Developmental cell - 11 Jul 2016
Hong Lilan, Dumond Mathilde, Tsugawa Satoru, Sapala Aleksandra, Routier-Kierzkowska Anne-Lise, Zhou Yong, Chen Catherine, Kiss Annamaria, Zhu Mingyuan, Hamant Olivier, Smith Richard S, Komatsuzaki Tamiki, Li Chun-Biu, Boudaoud Arezki, Roeder Adrienne H K
Abstract excerpt
Organ sizes and shapes are strikingly reproducible, despite the variable growth and division of individual cells within them. To reveal which mechanisms enable this precision, we designed a screen for disrupted sepal size and shape uniformity in Arabidopsis and identified mutations in the mitochondrial i-AAA protease FtsH4. Counterintuitively, through live imaging we observed that variability of neighboring cell...
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