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Article

A Phase II Study of Third-Line Combination Chemotherapy with Bevacizumab Plus S-1 for Metastatic Colorectal Cancer with Mutated KRAS (SAVIOR Study).

Oncology - 1 Jan 2016

Yoshida Motoki, Takagane Akinori, Miyake Yasuhiro, Shimada Ken, Nagata Naoki, Sato Atsushi, Ogata Yutaka, Fukunaga Mutsumi, Otsuka Koki, Takahashi Takao, Matsumoto Hidetomo, Kagimura Tatsuo, Tsuji Akihito

Abstract excerpt

OBJECTIVE: No salvage treatment had been established for metastatic colorectal cancer (mCRC) with mutated KRAS before the emergence of the new drugs regorafenib and TAS-102. We performed a phase II study of third-line chemotherapy with combined bevacizumab and S-1 for mCRC. METHODS: Subjects were mCRC patients with mutated KRAS who showed disease aggravation even after two regimens with oxaliplatin and...

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Identifiers

PMID: 27229742
DOI: 10.1159/000446372

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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