Article
Visual Prognosis in USH2A-Associated Retinitis Pigmentosa Is Worse for Patients with Usher Syndrome Type IIa Than for Those with Nonsyndromic Retinitis Pigmentosa.
Ophthalmology - 1 May 2016
Pierrache Laurence H M, Hartel Bas P, van Wijk Erwin, Meester-Smoor Magda A, Cremers Frans P M, de Baere Elfride, de Zaeytijd Julie, van Schooneveld Mary J, Cremers Cor W R J, Dagnelie Gislin, Hoyng Carel B, Bergen Arthur A, Leroy Bart P, Pennings Ronald J E, van den Born L Ingeborgh, Klaver Caroline C W
Abstract excerpt
PURPOSE: USH2A mutations are an important cause of retinitis pigmentosa (RP) with or without congenital sensorineural hearing impairment. We studied genotype-phenotype correlations and compared visual prognosis in Usher syndrome type IIa and nonsyndromic RP. DESIGN: Clinic-based, longitudinal, multicenter study. PARTICIPANTS: Consecutive patients with Usher syndrome type IIa (n = 152) and nonsyndromic RP (n = 73)...
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