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Increased yield of actionable mutations using multi-gene panels to assess hereditary cancer susceptibility in an ethnically diverse clinical cohort.

Cancer genetics - 1 Apr 2016

Ricker Charité, Culver Julie O, Lowstuter Katrina, Sturgeon Duveen, Sturgeon Julia D, Chanock Christopher R, Gauderman William J, McDonnell Kevin J, Idos Gregory E, Gruber Stephen B

Abstract excerpt

This study aims to assess multi-gene panel testing in an ethnically diverse clinical cancer genetics practice. We conducted a retrospective study of individuals with a personal or family history of cancer undergoing clinically indicated multi-gene panel tests of 6-110 genes, from six commercial laboratories. The 475 patients in the study included 228 Hispanics (47.6%), 166 non-Hispanic Whites (35.4%), 55 Asians...

Topics

Cohort Studies
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Mutation
Neoplasms
Retrospective Studies
Risk Assessment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26908360
DOI: 10.1016/j.cancergen.2015.12.013
PMCID: PMC4835267

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