Article
Complex genomic variants contribute toward the genetic architecture of autism spectrum disorder.
Psychiatric genetics - 1 Apr 2016
Chen Chia-Hsiang, Liao Hsiao-Mei, Chen Hsin-I, Fang Jye-Siung, Chen Yan-Jang, Lee Kuei-Fang, Gau Susan Shur-Fen
Abstract excerpt
Genetic factor plays a critical role in the etiology of autism spectrum disorder (ASD). Both common variants with a small effect and rare mutations with a large effect contribute toward the genetic basis of ASD, showing the high genetic heterogeneity of ASD. Genomic rearrangements account for around 10-15% of its genetic landscape. However, they are highly individualized and each of them has a very rare frequency.
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