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Article

A comprehensive meta-analysis of ZNF804A SNPs in the risk of schizophrenia among Asian populations.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2016

Huang Liang, Ohi Kazutaka, Chang Hong, Yu Hao, Wu Lichuan, Yue Weihua, Zhang Dai, Gao Lei, Li Ming

Abstract excerpt

Common variants in ZNF804A increased the risk of schizophrenia (and bipolar disorder), with low effect sizes in Europeans, which is in line with the polygenic nature of the illnesses, and implies that genetic analyses in small samples may not be sufficient to detect stable results. This notion is supported by the inconsistent replications of ZNF804A variations among individual small Asian samples, indicating the...

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PMID: 26866941
DOI: 10.1002/ajmg.b.32425

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