Article
The Presence of Clitoromegaly in the Nonclassical Form of 21-Hydroxylase Deficiency Could Be Partially Modulated by the CAG Polymorphic Tract of the Androgen Receptor Gene.
PloS one - 1 Jan 2016
Moura-Massari Vivian Oliveira, Cunha Flávia Siqueira, Gomes Larissa Garcia, Bugano Diniz Gomes Diogo, Marcondes José Antônio Miguel, Madureira Guiomar, de Mendonca Berenice Bilharinho, Bachega Tânia A Sartori Sanchez
Abstract excerpt
BACKGROUND: In the nonclassical form (NC), good correlation has been observed between genotypes and 17OH-progesterone (17-OHP) levels. However, this correlation was not identified with regard to the severity of hyperandrogenic manifestations, which could depend on interindividual variability in peripheral androgen sensitivity. Androgen action is modulated by the polymorphic CAG tract (nCAG) of the androgen...
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