Article
Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2016
Clark Owen, Yen Katharine, Mellinghoff Ingo K
Abstract excerpt
IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to α-ketoglutarate (α-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma. The mutant protein loses its normal enzymatic...
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