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Article

Mutational analysis of TBK1 in Taiwanese patients with amyotrophic lateral sclerosis.

Neurobiology of aging - 1 Apr 2016

Tsai Pei-Chien, Liu Yi-Chien, Lin Kon-Ping, Liu Yo-Tsen, Liao Yi-Chu, Hsiao Cheng-Tsung, Soong Bing-Wen, Yip Ping-Keung, Lee Yi-Chung

Abstract excerpt

Mutations in the TBK1 gene were just recently identified to cause amyotrophic lateral sclerosis (ALS), and their role in ALS in various populations remains unclear. The aim of this study was to determine the frequency and spectrum of mutations in TBK1 in a Taiwanese ALS cohort of Han Chinese origin. Mutational analyses of TBK1 were carried out by direct nucleotide sequencing in a cohort of 207 unrelated patients...

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Source

Identifiers

PMID: 26804609
DOI: 10.1016/j.neurobiolaging.2015.12.022

Genes

TBK1
ATXN2
CHCHD10
FUS
HNRNPA1
MATR3
OPTN
PFN1
SOD1
SQSTM1
TANK
TARDBP
UBQLN2
VCP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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