Article
Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes.
Nature communications - 7 Jan 2016
Lorenzi Hernan, Khan Asis, Behnke Michael S, Namasivayam Sivaranjani, Swapna Lakshmipuram S, Hadjithomas Michalis, Karamycheva Svetlana, Pinney Deborah, Brunk Brian P, Ajioka James W, Ajzenberg Daniel, Boothroyd John C, Boyle Jon P, Dardé Marie L, Diaz-Miranda Maria A, Dubey Jitender P, Fritz Heather M, Gennari Solange M, Gregory Brian D, Kim Kami, Saeij Jeroen P J, Su Chunlei, White Michael W, Zhu Xing-Quan, Howe Daniel K, Rosenthal Benjamin M, Grigg Michael E, Parkinson John, Liu Liang, Kissinger Jessica C, Roos David S, Sibley L David
Abstract excerpt
Toxoplasma gondii is among the most prevalent parasites worldwide, infecting many wild and domestic animals and causing zoonotic infections in humans. T. gondii differs substantially in its broad distribution from closely related parasites that typically have narrow, specialized host ranges. To elucidate the genetic basis for these differences, we compared the genomes of 62 globally distributed T. gondii isolates...
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