Cell-free DNA Analysis for Noninvasive Examination of Trisomy

Abstract excerpt

ConclusionsIn this large, routine prenatal-screening population, cfDNA testing for trisomy 21 had higher sensitivity, a lower false positive rate, and higher positive predictive value than did standard screening with the measurement of nuchal translucency and biochemical analytes.(Funded by Ariosa Diagnostics and Perinatal Quality Foundation; NEXT ClinicalTrials.govnumber, NCT01511458.)

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