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Article

Different EGFR Gene Mutations in Exon 18, 19 and 21 as Prognostic and Predictive Markers in NSCLC: A Single Institution Analysis.

Molecular diagnosis & therapy - 1 Feb 2016

Rossi Sabrina, D'Argento Ettore, Basso Michele, Strippoli Antonia, Dadduzio Vincenzo, Cerchiaro Eleonora, Martini Maurizio, Cassano Alessandra, Barone Carlo

Abstract excerpt

BACKGROUND: Mutations of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) predict longer overall survival (OS) and response to EGFR tyrosine kinase inhibitors (TKIs). The clinical relevance of different mutations in terms of response to TKIs and prognosis is still unclear. OBJECTIVES: The aims of the present study were to assess the relationship between mutations in exon 18, 19 and 21...

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PMID: 26645830
DOI: 10.1007/s40291-015-0176-x

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EGFR

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