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Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth <i>In Vitro</i> and Proliferation <i>In Vivo</i>

8 Dec 2015

Abstract excerpt

The microbiome dysbiosis caused by antibiotic treatment has been associated with both susceptibility to and relapse of Clostridium difficile infection (CDI). Bacteriophage (phage) therapy offers target specificity and dose amplification in situ, but few studies have focused on its use in CDI treatment. This mainly reflects the lack of strictly virulent phages that target this pathogen. While it is widely accepted...

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PMID: 26643348
DOI: 10.1128/aac.01774-15

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