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A 10-gene expression signature of Notch pathway predicts recurrence in ovarian carcinoma

16 Jun 2015

Abstract excerpt

Patients with ovarian carcinoma are at high risk of tumor recurrence. In the present study, 81 Notch pathway genes were selected to find recurrence-related genes in The Cancer Genome Atlas dataset. A 10-gene signature (FZD4, HES1, PSEN2, JAG2, PPARG, FOS, HEY1, CDC16, MFNG, and EP300) was identified and validated that is associated with recurrence-free survival time, but not with overall survival time, in the...

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PMID: 26622736
DOI: 10.3892/ol.2015.3382

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