Article
Variants in KCNJ11 and BAD do not predict response to ketogenic dietary therapies for epilepsy.
Epilepsy research - 1 Dec 2015
Schoeler Natasha E, Leu Costin, White Jon, Plagnol Vincent, Ellard Sian, Matarin Mar, Yellen Gary, Thiele Elizabeth A, Mackay Mark, McMahon Jacinta M, Scheffer Ingrid E, Sander Josemir W, Cross J Helen, Sisodiya Sanjay M
Abstract excerpt
In the absence of specific metabolic disorders, predictors of response to ketogenic dietary therapies (KDT) are unknown. We aimed to determine whether variants in established candidate genes KCNJ11 and BAD influence response to KDT. We sequenced KCNJ11 and BAD in individuals without previously-known glucose transporter type 1 deficiency syndrome or other metabolic disorders, who received KDT for epilepsy....
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