Article
Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity.
Scientific reports - 17 Nov 2015
Mitra A, MacIntyre D A, Lee Y S, Smith A, Marchesi J R, Lehne B, Bhatia R, Lyons D, Paraskevaidis E, Li J V, Holmes E, Nicholson J K, Bennett P R, Kyrgiou M
Abstract excerpt
Persistent infection with oncogenic Human Papillomavirus (HPV) is necessary for cervical carcinogenesis. Although evidence suggests that the vaginal microbiome plays a functional role in the persistence or regression of HPV infections, this has yet to be described in women with cervical intra-epithelial neoplasia (CIN). We hypothesised that increasing microbiome diversity is associated with increasing CIN...
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