Article
Inhibition of fucosylation of cell wall components by 2-fluoro 2-deoxy-L-fucose induces defects in root cell elongation.
The Plant journal : for cell and molecular biology - 1 Dec 2015
Dumont Marie, Lehner Arnaud, Bardor Muriel, Burel Carole, Vauzeilles Boris, Lerouxel Olivier, Anderson Charles T, Mollet Jean-Claude, Lerouge Patrice
Abstract excerpt
Screening of commercially available fluoro monosaccharides as putative growth inhibitors in Arabidopsis thaliana revealed that 2-fluoro 2-l-fucose (2F-Fuc) reduces root growth at micromolar concentrations. The inability of 2F-Fuc to affect an Atfkgp mutant that is defective in the fucose salvage pathway indicates that 2F-Fuc must be converted to its cognate GDP nucleotide sugar in order to inhibit root growth....
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