Article
Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene.
The American journal of clinical nutrition - 1 Dec 2015
Kuehnelt Doris, Engström Karin, Skröder Helena, Kokarnig Sabine, Schlebusch Carina, Kippler Maria, Alhamdow Ayman, Nermell Barbro, Francesconi Kevin, Broberg Karin, Vahter Marie
Abstract excerpt
BACKGROUND: Selenium is an essential element, but its metabolism in humans is not well characterized. A few small studies indicate that the trimethylselenonium ion (TMSe) is a common selenium metabolite in humans. OBJECTIVE: This study aimed to elucidate the human metabolism of selenium to TMSe. DESIGN: Study individuals constituted subsamples of 2 cohorts: 1) pregnant women (n = 228) and their 5-y-old children...
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