Article
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.
Cancer cell - 9 Nov 2015
Best Myron G, Sol Nik, Kooi Irsan, Tannous Jihane, Westerman Bart A, Rustenburg François, Schellen Pepijn, Verschueren Heleen, Post Edward, Koster Jan, Ylstra Bauke, Ameziane Najim, Dorsman Josephine, Smit Egbert F, Verheul Henk M, Noske David P, Reijneveld Jaap C, Nilsson R Jonas A, Tannous Bakhos A, Wesseling Pieter, Wurdinger Thomas
Abstract excerpt
Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and local responses to tumor growth, thereby altering their RNA profile. We determined the diagnostic potential of TEPs by mRNA sequencing of 283 platelet samples. We distinguished 228 patients with localized and metastasized tumors from 55 healthy individuals with 96% accuracy. Across six different tumor types, the location...
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