Article
The Region of Difference Four is a Robust Genetic Marker for Subtyping Mycobacterium caprae Isolates and is Linked to Spatial Distribution of Three Subtypes.
Transboundary and emerging diseases - 1 Jun 2017
Rettinger A, Broeckl S, Fink M, Prodinger W M, Blum H, Krebs S, Domogalla J, Just F, Gellert S, Straubinger R K, Büttner M
Abstract excerpt
Alpine Mycobacterium caprae isolates found in cattle and red deer display at least three genetic variations in the region of difference four (RD4) that can be used for further differentiation of the isolates into the subtypes 'Allgäu', 'Karwendel' and 'Lechtal'. Each genomic subtype is thereby characterized by a specific nucleotide deletion pattern in the 12.7-kb RD4 region. Even though M. caprae infections are...
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