The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.

doi:10.3233/JAD-150257

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The Latent Dementia Phenotype δ is Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Predicts Conversion to Dementia in Subjects with Mild Cognitive Impairment.

Journal of Alzheimer's disease : JAD - 1 Jan 2016

Koppara Alexander, Wolfsgruber Steffen, Kleineidam Luca, Schmidtke Klaus, Frölich Lutz, Kurz Alexander, Schulz Stefanie, Hampel Harald, Heuser Isabella, Peters Oliver, Reischies Friedel M, Jahn Holger, Luckhaus Christian, Hüll Michael, Gertz Hermann-Josef, Schröder Johannes, Pantel Johannes, Rienhoff Otto, Rüther Eckart, Henn Fritz, Wiltfang Jens, Maier Wolfgang, Jessen Frank, Kornhuber Johannes, Wagner Michael

Abstract excerpt

BACKGROUND: The recently proposed latent variable δ is a new tool for dementia case finding. It is built in a structural equation modeling framework of cognitive and functional data and constitutes a novel endophenotype for Alzheimer's disease (AD) research and clinical trials. OBJECTIVE: To investigate the association of δ with AD biomarkers and to compare the prediction of δ with established scales for...

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PMID: 26484902
DOI: 10.3233/JAD-150257

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