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Article

Comparative In Vitro and In Vivo Studies of Porcine Rotavirus G9P[13] and Human Rotavirus Wa G1P[8].

Journal of virology - 1 Jan 2016

Shao Lulu, Fischer David D, Kandasamy Sukumar, Rauf Abdul, Langel Stephanie N, Wentworth David E, Stucker Karla M, Halpin Rebecca A, Lam Ham Ching, Marthaler Douglas, Saif Linda J, Vlasova Anastasia N

Abstract excerpt

UNLABELLED: The changing epidemiology of group A rotavirus (RV) strains in humans and swine, including emerging G9 strains, poses new challenges to current vaccines. In this study, we comparatively assessed the pathogenesis of porcine RV (PRV) G9P[13] and evaluated the short-term cross-protection between this strain and human RV (HRV) Wa G1P[8] in gnotobiotic pigs. Complete genome sequencing demonstrated that PRV...

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Identifiers

PMID: 26468523
DOI: 10.1128/JVI.02401-15
PMCID: PMC4702550

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