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Article

Methylenetetrahydrofolate Reductase C677T: Hypoplastic Left Heart and Thrombosis.

World journal for pediatric & congenital heart surgery - 1 Oct 2015

Spronk Kimberly J, Olivero Anthony D, Haw Marcus P, Vettukattil Joseph J

Abstract excerpt

The incidence of congenital heart defects is higher in infants with mutation of methylenetetrahydrofolate reductase (MTHFR) gene. The MTHFR C677T gene decreases the bioavailability of folate and increases plasma homocysteine, a risk factor for thrombosis. There have been no reported cases in the literature on the clinical implications of this procoagulable state in the setting of cyanotic heart disease, which...

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Share to Cardiac Surgical Procedures
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Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Infant, Newborn

Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Share to Venous Thrombosis

Source

Identifiers

PMID: 26467879
DOI: 10.1177/2150135115577670

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylenetetrahydrofolate Reductase C677T: Hypoplastic Left Heart and Thrombosis.PMID 26467879Read ↗

Thrombus obstructing the right ventricle outflow tract in a neonate with methylenetetrahydrofolate reductase 677TT genotype.Semantic proximity Read ↗

Analysis of prothrombotic mutations and polymorphisms in children who developed thrombosis in the perioperative period of congenital cardiac surgery.Semantic proximity Read ↗

Heterozygous methylenetetrahydrofolate reductase 677C-T gene mutation with mild hyperhomocysteinemia associated with intrauterine iliofemoral artery thrombosis.Semantic proximity Read ↗

Consistent Correlation between MTHFR and Vascular Thrombosis in Neonates—Case Series and Clinical ConsiderationsSemantic proximity Read ↗

Cardiac transplant in a child with recurrent thrombosis due to congenital thrombophilic mutations.Semantic proximity Read ↗

Myocardial infarction in a newborn heterozygous for the MTHFR C677T mutation.Semantic proximity Read ↗

Association of the C677T methylenetetrahydrofolate reductase mutation and elevated homocysteine levels with congenital cardiac malformationsSemantic proximity Read ↗

Dual mutation (MTHFR A1298C with PAI (4G) mutation) manifesting with bilateral lower limb gangrene in a neonate.Semantic proximity Read ↗

Renal venous thrombosis in a newborn with prothrombotic risk factors.Semantic proximity Read ↗

[Cerebral sinovenous thrombosis in a newborn with mutation of MTHFR C677T treated with enoxaparin].Semantic proximity Read ↗

Thrombosis in children with cardiac pathology: frequency of factor V Leiden and prothrombin G20210A mutations.Semantic proximity Read ↗

Hyperhomocysteinemia-induced upper extremity deep vein thrombosis and pulmonary embolism in a patient with methyltetrahydrofolate reductase mutation: a case report and literature review.Semantic proximity Read ↗

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