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Article

Leucine metabolism regulates TRI6 expression and affects deoxynivalenol production and virulence in Fusarium graminearum.

Molecular microbiology - 1 Nov 2015

Subramaniam Rajagopal, Narayanan Swara, Walkowiak Sean, Wang Li, Joshi Manisha, Rocheleau Hélène, Ouellet Thérèse, Harris Linda J

Abstract excerpt

TRI6 is a positive regulator of the trichothecene gene cluster and the production of trichothecene mycotoxins [deoxynivalenol (DON)] and acetylated forms such as 15-Acetyl-DON) in the cereal pathogen Fusarium graminearum. As a global transcriptional regulator, TRI6 expression is modulated by nitrogen-limiting conditions, sources of nitrogen and carbon, pH and light. However, the mechanism by which these diverse...

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PMID: 26248604
DOI: 10.1111/mmi.13155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Leucine metabolism regulates TRI6 expression and affects deoxynivalenol production and virulence in Fusarium graminearum.PMID 26248604Read ↗

Activation of biosynthetic gene clusters by the global transcriptional regulator TRI6 in Fusarium graminearumSemantic proximity Read ↗

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Combined Metabonomic and Quantitative Real-Time PCR Analyses Reveal Systems Metabolic Changes of <i>Fusarium graminearum</i> Induced by <i>Tri5</i> Gene DeletionSemantic proximity Read ↗

A Novel Trichothecene Toxin Phenotype Associated with Horizontal Gene Transfer and a Change in Gene Function in Fusarium.Semantic proximity Read ↗

Fusarium graminearum TRI14 is required for high virulence and DON production on wheat but not for DON synthesis in vitro.Semantic proximity Read ↗

Structural and functional characterization of TRI3 trichothecene 15-O-acetyltransferase from Fusarium sporotrichioides.Semantic proximity Read ↗

Tri1 encodes the cytochrome P450 monooxygenase for C-8 hydroxylation during trichothecene biosynthesis in Fusarium sporotrichioides and resides upstream of another new Tri gene.Semantic proximity Read ↗

Transcriptome analysis of trichothecene-induced gene expression in barley.Semantic proximity Read ↗

Attempting to Create a Pathway to 15-Deacetylcalonectrin with Limited Accumulation in Cultures of Fusarium Tri3 Mutants: Insight into Trichothecene Biosynthesis Machinery.Semantic proximity Read ↗

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Comparative secretome analysis of Fusarium graminearum and two of its non-pathogenic mutants upon deoxynivalenol induction in vitro.Semantic proximity Read ↗

Substrate specificities of Fusarium biosynthetic enzymes explain the genetic basis of a mixed chemotype producing both deoxynivalenol and nivalenol-type trichothecenes.Semantic proximity Read ↗

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