Article
Pathway analysis supports association of nonsyndromic cryptorchidism with genetic loci linked to cytoskeleton-dependent functions.
Human reproduction (Oxford, England) - 1 Oct 2015
Barthold Julia Spencer, Wang Yanping, Kolon Thomas F, Kollin Claude, Nordenskjöld Agneta, Olivant Fisher Alicia, Figueroa T Ernesto, BaniHani Ahmad H, Hagerty Jennifer A, Gonzaléz Ricardo, Noh Paul H, Chiavacci Rosetta M, Harden Kisha R, Abrams Debra J, Kim Cecilia E, Li Jin, Hakonarson Hakon, Devoto Marcella
Abstract excerpt
STUDY QUESTION: What are the genetic loci that increase susceptibility to nonsyndromic cryptorchidism, or undescended testis? SUMMARY ANSWER: A genome-wide association study (GWAS) suggests that susceptibility to cryptorchidism is heterogeneous, with a subset of suggestive signals linked to cytoskeleton-dependent functions and syndromic forms of the disease. WHAT IS KNOWN ALREADY: Population studies suggest...
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