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Article

Fsh Stimulates Spermatogonial Proliferation and Differentiation in Zebrafish via Igf3.

Endocrinology - 1 Oct 2015

Nóbrega Rafael Henrique, Morais Roberto Daltro Vidal de Souza, Crespo Diego, de Waal Paul P, de França Luiz Renato, Schulz Rüdiger W, Bogerd Jan

Abstract excerpt

Growth factors modulate germ line stem cell self-renewal and differentiation behavior. We investigate the effects of Igf3, a fish-specific member of the igf family. Fsh increased in a steroid-independent manner the number and mitotic index of single type A undifferentiated spermatogonia and of clones of type A differentiating spermatogonia in adult zebrafish testis. All 4 igf gene family members in zebrafish are...

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Identifiers

PMID: 26207345
DOI: 10.1210/en.2015-1157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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