Article
Pseudomonas aeruginosa Biofilm Formation and Persistence, along with the Production of Quorum Sensing-Dependent Virulence Factors, Are Disrupted by a Triterpenoid Coumarate Ester Isolated from Dalbergia trichocarpa, a Tropical Legume.
PloS one - 1 Jan 2015
Rasamiravaka Tsiry, Vandeputte Olivier M, Pottier Laurent, Huet Joelle, Rabemanantsoa Christian, Kiendrebeogo Martin, Andriantsimahavandy Abel, Rasamindrakotroka Andry, Stévigny Caroline, Duez Pierre, El Jaziri Mondher
Abstract excerpt
Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in biofilm formation. One of the active compounds has been isolated and identified as oleanolic aldehyde coumarate (OALC), a novel bioactive compound that inhibits the formation of P. aeruginosa PAO1 biofilm and its...
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