Article
Effect of ivacaftor therapy on exhaled nitric oxide in patients with cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Nov 2015
Grasemann Hartmut, Gonska Tanja, Avolio Julie, Klingel Michelle, Tullis Elizabeth, Ratjen Felix
Abstract excerpt
UNLABELLED: Airways of patients with cystic fibrosis are deficient for nitric oxide. Low nitric oxide in cystic fibrosis has been shown to be associated with poor pulmonary function and risk of infection with certain pathogens. Treatment of cystic fibrosis patients with the cystic fibrosis transmembrane conductance regulator (CFTR)-targeting drug ivacaftor results in improved pulmonary function. The effect of...
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