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Article

No evidence for clinical utility in investigating the connexin genes GJB2, GJB6 and GJA1 in non-syndromic hearing loss in black Africans.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde - 1 Jan 2015

Wonkam A, Bosch J, Noubiap J J N, Lebeko K, Makubalo N, Dandara C

Abstract excerpt

BACKGROUND: Deafness is the most common sensory disability in the world. Globally, mutations in GJB2 (connexin 26) have been shown to play a major role in non-syndromic deafness. Two other connexin genes, GJB6 (connexin 30) and GJA1 (connexin 43), have been implicated in hearing loss, but these genes have seldom been investigated in black Africans. We aimed to validate the utility of testing for GJB2, GJB6 and...

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Source

Identifiers

PMID: 26046157
DOI: 10.7196/samj.8814

Genes

GJB6
GJA1
GJB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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No evidence for clinical utility in investigating the connexin genes GJB2, GJB6 and GJA1 in non-syndromic hearing loss in black Africans.PMID 26046157Read ↗

In search of genetic markers for nonsyndromic deafness in Africa: a study in Cameroonians and Black South Africans with the GJB6 and GJA1 candidate genes.Semantic proximity Read ↗

Sequencing of GJB2 in Cameroonians and Black South Africans and comparison to 1000 Genomes Project Data Support Need to Revise Strategy for Discovery of Nonsyndromic Deafness Genes in Africans.Semantic proximity Read ↗

GJB2 and GJB6 Mutations in Hereditary Recessive Non-Syndromic Hearing Impairment in Cameroon.Semantic proximity Read ↗

Absence of GJB2 gene mutations, the GJB6 deletion (GJB6-D13S1830) and four common mitochondrial mutations in nonsyndromic genetic hearing loss in a South African population.Semantic proximity Read ↗

Connexin gene mutations among Ugandan patients with nonsyndromic sensorineural hearing loss.Semantic proximity Read ↗

Genetics of hearing loss in Africans: use of next generation sequencing is the best way forward.Semantic proximity Read ↗

Absence of GJB6 mutations in Indian patients with non-syndromic hearing loss.Semantic proximity Read ↗

Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness.Semantic proximity Read ↗

A study of GJB2 and delGJB6-D13S1830 mutations in Brazilian non-syndromic deaf children from the Amazon region.Semantic proximity Read ↗

Mutations in GJB2, GJB6, and mitochondrial DNA are rare in African American and Caribbean Hispanic individuals with hearing impairment.Semantic proximity Read ↗

Efficacy of Connexin testing in detecting Non-syndromic Sensorineural Hearing Loss in an Indian cohortSemantic proximity Read ↗

Absence of GJB3 and GJB6 mutations in Moroccan familial and sporadic patients with autosomal recessive non-syndromic deafness.Semantic proximity Read ↗

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