Article
Impact of body surface area on survival in EGFR-mutant non-small cell lung cancer patients treated with gefitinib monotherapy: observational study of the Okayama Lung Cancer Study Group 0703.
Cancer chemotherapy and pharmacology - 1 Aug 2015
Kudo Kenichiro, Hotta Katsuyuki, Ichihara Eiki, Yoshioka Hiroshige, Kunimasa Kei, Tsubouchi Kazuya, Iwasaku Masahiro, Kato Yuka, Oze Isao, Takigawa Nagio, Tanimoto Mitsune, Kiura Katsuyuki
Abstract excerpt
BACKGROUND: The approved dose of gefitinib is fixed, without adjustment for physical size. We demonstrated previously that its efficacy was affected by body surface area (BSA) in patients with EGFR-mutant non-small cell lung cancer (NSCLC). To validate these observations, we assessed the association between BSA and the efficacy of gefitinib using a different patient cohort. METHODS: Prospective cohort data from...
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