Neuropathologic assessment of participants in two multi‐center longitudinal observational studies: The A lzheimer D isease N euroimaging I nitiative ( ADNI ) and the D ominantly I nherited A lzheimer N etwork ( DIAN )

Abstract excerpt

It has been hypothesized that the relatively rare autosomal dominant Alzheimer disease (ADAD) may be a useful model of the more frequent, sporadic, late-onset AD (LOAD). Individuals with ADAD have a predictable age at onset and the biomarker profile of ADAD participants in the preclinical stage may be used to predict disease progression and clinical onset. However, the extent to which the pathogenesis and...