Article
Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity.
eLife - 28 Apr 2015
Pope Welkin H, Bowman Charles A, Russell Daniel A, Jacobs-Sera Deborah, Asai David J, Cresawn Steven G, Jacobs William R, Hendrix Roger W, Lawrence Jeffrey G, Hatfull Graham F
Abstract excerpt
The bacteriophage population is large, dynamic, ancient, and genetically diverse. Limited genomic information shows that phage genomes are mosaic, and the genetic architecture of phage populations remains ill-defined. To understand the population structure of phages infecting a single host strain, we isolated, sequenced, and compared 627 phages of Mycobacterium smegmatis. Their genetic diversity is considerable,...
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