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Article

Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function.

The Journal of biological chemistry - 5 Jun 2015

Chandrachud Uma, Walker Mathew W, Simas Alexandra M, Heetveld Sasja, Petcherski Anton, Klein Madeleine, Oh Hyejin, Wolf Pavlina, Zhao Wen-Ning, Norton Stephanie, Haggarty Stephen J, Lloyd-Evans Emyr, Cotman Susan L

Abstract excerpt

Abnormal accumulation of undigested macromolecules, often disease-specific, is a major feature of lysosomal and neurodegenerative disease and is frequently attributed to defective autophagy. The mechanistic underpinnings of the autophagy defects are the subject of intense research, which is aided by genetic disease models. To gain an improved understanding of the pathways regulating defective autophagy...

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Source

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Identifiers

PMID: 25878248
DOI: 10.1074/jbc.M114.621706
PMCID: PMC4505505

Genes

CLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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