Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis.

doi:10.1038/ncomms7740

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Article

Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis.

Nature communications - 31 Mar 2015

Weinert Lucy A, Chaudhuri Roy R, Wang Jinhong, Peters Sarah E, Corander Jukka, Jombart Thibaut, Baig Abiyad, Howell Kate J, Vehkala Minna, Välimäki Niko, Harris David, Chieu Tran Thi Bich, Van Vinh Chau Nguyen, Campbell James, Schultsz Constance, Parkhill Julian, Bentley Stephen D, Langford Paul R, Rycroft Andrew N, Wren Brendan W, Farrar Jeremy, Baker Stephen, Hoa Ngo Thi, Holden Matthew T G, Tucker Alexander W, Maskell Duncan J

Abstract excerpt

Streptococcus suis causes disease in pigs worldwide and is increasingly implicated in zoonotic disease in East and South-East Asia. To understand the genetic basis of disease in S. suis, we study the genomes of 375 isolates with detailed clinical phenotypes from pigs and humans from the United Kingdom and Vietnam. Here, we show that isolates associated with disease contain substantially fewer genes than...

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PMID: 25824154
DOI: 10.1038/ncomms7740
PMCID: PMC4389249

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