Article
A systems genetics study of swine illustrates mechanisms underlying human phenotypic traits.
BMC genomics - 14 Feb 2015
Zhu Jun, Chen Congying, Yang Bin, Guo Yuanmei, Ai Huashui, Ren Jun, Peng Zhiyu, Tu Zhidong, Yang Xia, Meng Qingying, Friend Stephen, Huang Lusheng
Abstract excerpt
BACKGROUND: The pig, which shares greater similarities with human than with mouse, is important for agriculture and for studying human diseases. However, similarities in the genetic architecture and molecular regulations underlying phenotypic variations in humans and swine have not been systematically assessed. RESULTS: We systematically surveyed ~500 F2 pigs genetically and phenotypically. By comparing...
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