Article
Macrolide-resistant Streptococcus pyogenes: prevalence and treatment strategies.
Expert review of anti-infective therapy - 1 May 2015
Silva-Costa Catarina, Friães Ana, Ramirez Mario, Melo-Cristino Jose
Abstract excerpt
Although penicillin remains the first-choice treatment for Streptococcus pyogenes infection, macrolides are important alternatives for allergic patients and lincosamides are recommended together with β-lactams in invasive infections. S. pyogenes may exhibit macrolide resistance because of active efflux (mef genes) or target modification (erm genes), the latter conferring cross resistance to lincosamides and...
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