Article
Characterization of patients with angioedema without wheals: the importance of F12 gene screening.
Clinical immunology (Orlando, Fla.) - 1 Apr 2015
Firinu Davide, Bafunno Valeria, Vecchione Gennaro, Barca Maria Pina, Manconi Paolo Emilio, Santacroce Rosa, Margaglione Maurizio, Del Giacco Stefano R
Abstract excerpt
Sporadic and familiar forms of non-histaminergic angioedema and normal C1 inhibitor encompass a group of disorders possibly caused by bradikinin. We aimed to study the subgroups of hereditary angioedema with FXII mutation (FXII-HAE), unknown genetic defect (U-HAE) and idiopathic non-histaminergic acquired angioedema (InH-AAE). We screened the F12 locus in our cohort and delineated the clinical, laboratory and...
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