Article
Lack of an association between diffuse systemic sclerosis and HLA-DR1 or HLA-DR5.
Disease markers - 1 Jan 2000
Kratz L E, Boughman J A, Needleman B W
Abstract excerpt
The HLA-DR locus of the major histocompatibility complex encodes class II molecules which participate in immune responses through regulation of T cell interaction with antigen presenting cells. Previous association studies between HLA-DR antigens and the autoimmune disease, systemic sclerosis (or scleroderma), have yielded conflicting results. Some investigators have reported an association between this disease...
Topics
- Alleles
- DNA
- Disease Susceptibility
- Gene Frequency
- HLA-DR1 Antigen
- HLA-DR5 Antigen
- Humans
- Polymorphism, Restriction Fragment Length
- Scleroderma, Systemic